What question did this study set out to answer?

To review the structural classification, conformational dynamics, and transport mechanisms of the major facilitator superfamily, with a primary focus on sugar porters such as GLUT1.

June 22, 2015Annual Review of Biophysics

Structural Biology of the Major Facilitator Superfamily Transporters

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To review the structural classification, conformational dynamics, and transport mechanisms of the major facilitator superfamily, with a primary focus on sugar porters such as GLUT1.
Synthesized historical and recent structural biology breakthroughs across the major facilitator superfamily.
Analyzed structural models and molecular mechanics underlying substrate binding, alternating access, and cotransport coupling.
Identified structural frameworks enabling MFS secondary transporters to mediate the movement of diverse solutes and ions via facilitated diffusion, symport, and antiport.
Elucidated the molecular basis of alternating access and substrate coordination using high-resolution structures of sugar porters including GLUT1.

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Implication

Structural review uncovers the mechanisms of alternating access and substrate transport in major facilitator superfamily proteins, highlighting foundational principles of cellular transport.

Cite This Study

Nieng Yan (2015) studied this question.

synapsesocial.com/papers/69d9446eccb0bba5a568487f https://doi.org/10.1146/annurev-biophys-060414-033901

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Implication

Structural review uncovers the mechanisms of alternating access and substrate transport in major facilitator superfamily proteins, highlighting foundational principles of cellular transport.

Structural Biology of the Major Facilitator Superfamily Transporters

Key Points

Discussion

Implication

Cite This Study

Structural Biology of the Major Facilitator Superfamily Transporters

Key Points

Discussion

Implication

Cite This Study

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