This study demonstrates for the first time that plasma exosomal miRNA profiles are significantly altered in bullous pemphigoid (BP). We identified let-7i-5p as a promising biomarker, whose expression inversely correlates with disease activity and independently predicts higher risks of relapse and infection. Exosomal let-7i-5p may serve as an objective tool for disease monitoring and risk stratification in BP.
Zhang et al. (Thu,) studied this question.