Does TAVR for bicuspid aortic stenosis reduce mortality or stroke compared to TAVR for tricuspid aortic stenosis in patients at low surgical risk?
In low surgical risk patients undergoing TAVR, there was no significant difference in mortality or stroke at 1 year between those with bicuspid versus tricuspid aortic stenosis.
In this preliminary, registry-based study of propensity-matched patients at low surgical risk who had undergone TAVR for aortic stenosis, patients treated for bicuspid vs tricuspid aortic stenosis had no significant difference in mortality or stroke at 30 days or 1 year. Because of the potential for selection bias and absence of a control group treated surgically for bicuspid aortic stenosis, randomized trials are needed to adequately assess the efficacy and safety of transcatheter aortic valve replacement for bicuspid aortic stenosis in patients at low surgical risk.
Makkar et al. (Tue,) studied this question.