Neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, involve the gradual loss of neurons, often caused by oxidative stress, inflammation, and imbalances in neurotransmitters. Current treatments offer limited benefits, making it crucial to explore new approaches for protecting the brain. Probiotics are beneficial microbes that have gained attention for their ability to influence the gut–brain connection and support brain health through antioxidant and anti-inflammatory effects, as well as regulation of neurotransmitters. One promising source of such probiotics is the nectar of Spathodea campanulata, also known as the African tulip tree, which is rich in bioactive compounds and hosts diverse microbial communities. Emerging research suggests that probiotics from this nectar may help protect neurons by reducing oxidative stress and inflammation. This review brings together current knowledge on the neuroprotective roles of nectar-derived probiotic strains, explaining how they work and their potential therapeutic benefits. It also highlights areas where more research is needed and discusses the future possibilities of using these natural probiotics to help prevent or manage neurodegenerative diseases in a safe and multi-targeted way.
Vinitha et al. (Wed,) studied this question.