Abstract LB376: Historical redlining and DNA methylation in prostate tumors
Why the study?
Is residence in a historically redlined neighborhood associated with prostate tumor DNA methylation alterations in African American men with prostate cancer?
Population
92 African American men with prostate cancer who received radical prostatectomy at the University of…
Comparison
Residence in a historically redlined neighborhood vs Residence in a non-redlined neighborhood
Design
Cross-sectional
Key result
Residence in a historically redlined neighborhood was associated with significant prostate tumor DNA methylation differences at 12 CpG sites in African American men (FDR-adjusted p<0.05).
Authors
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May warrant residential history in PC risk assessment for AA men; extends ND research by implicating epigenetic mediators of racial disparities.
Cross-Sectional (n=92)
No
Is residence in a historically redlined neighborhood associated with prostate tumor DNA methylation alterations in African American men with prostate cancer?
Residence in historically redlined neighborhoods is associated with specific epigenetic alterations in prostate tumors among African American men, suggesting a biological mechanism linking structural racism to cancer disparities.
p-value: p=<0.05
Boyle et al. (2026) conducted a cross-sectional in Prostate cancer (n=92). Residence in a historically redlined neighborhood vs. Residence in a non-redlined neighborhood was evaluated on Prostate tumor DNA methylation (DNAm) levels (p=<0.05). Residence in a historically redlined neighborhood was associated with significant prostate tumor DNA methylation differences at 12 CpG sites in African American men (FDR-adjusted p<0.05).