Key result
Metabolic syndrome is linked to a ~135% higher risk of cardiovascular disease.
Why the study?
There is debate regarding the prognostic significance of the metabolic syndrome for cardiovascular outcomes as defined by NCEP and rNCEP criteria.
Does the metabolic syndrome increase the risk of cardiovascular outcomes and mortality?
Meta-Analysis (n=951,083)
Does the metabolic syndrome increase the risk of cardiovascular outcomes and mortality?
Relative Risk: 2.35 (95% CI 2.02–2.73)
The metabolic syndrome is associated with a roughly 2-fold increase in cardiovascular outcomes and a 1.5-fold increase in all-cause mortality.
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May warrant intensified risk factor modification in affected patients; leaves open whether syndrome confers risk beyond its components.
Mottillo et al. (2010) conducted a meta-analysis in Metabolic syndrome (n=951,083). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Cardiovascular disease (CVD) (RR 2.35, 95% CI 2.02 to 2.73). The metabolic syndrome was associated with an increased risk of cardiovascular disease (RR 2.35; 95% CI 2.02-2.73) and all-cause mortality (RR 1.58; 95% CI 1.39-1.78).