What question did this study set out to answer?

To evaluate nailfold capillary features in individuals with hypertension, diabetes mellitus, stroke, and chronic kidney disease compared to healthy controls.

April 22, 2026

Observational study of nailfold capillaroscopy features in hypertension, diabetes Mellitus, stroke, and chronic kidney disease: Associations and potential for early detection in cardiovascular and metabolic disorders

Key Points

To evaluate nailfold capillary features in individuals with hypertension, diabetes mellitus, stroke, and chronic kidney disease compared to healthy controls.
Conducted an observational study with 162 participants of varying health conditions.
Evaluated nailfold capillary features including vessel clarity, tubular collateral metrics, and perfusion rates.
Compared findings across five participant groups: hypertension, diabetes, stroke, CKD, and healthy controls.
Diabetes group showed reduced tubular collateral length and input tab diameter.
Stroke group exhibited reduced tubular collateral length and apex width, along with altered blood color.
Significantly lower perfused capillary density found in hypertension, diabetes mellitus, and stroke groups (P < 0.01).

Abstract

ObjectivesTo assess nailfold capillary (NFC) features in hypertension, diabetes mellitus (DM), stroke, and chronic kidney disease (CKD) versus healthy controls, and explore relationships between abnormalities.MethodsObservational study of 162 participants (69 M/93F, mean age 39.7 ± 13.16y). NFC evaluated vessel clarity, tubular collateral number/length, input/output tab diameters, apex diameter/width, granular flow rate, blood color ratio, perfused capillary density (PCD) in five groups.ResultsSignificant differences found vs. controls: DM group had reduced tubular collateral length and input tab diameter; Stroke group had reduced tubular collateral length and apex width, plus altered blood color distribution; CKD group had reduced vessel clarity; The PCD was significantly reduced in the hypertension, diabetes mellitus, and stroke groups(P < 0.01). Well-point sites had fewer tubular collaterals than non-well-point sites.ConclusionsSpecific NFC parameters (capillary length, width, blood color, clarity) provide reference values for assessing these cardiovascular/metabolic disorders. Well-point NFC may aid early detection/prevention.

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Cite This Study

Hongxu et al. (Mon,) studied this question.

synapsesocial.com/papers/69e866f16e0dea528ddeb4bb https://doi.org/https://doi.org/10.1177/13860291251414609

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