Key result
CMR characterizes replacement and diffuse interstitial myocardial fibrosis to guide therapeutic management.
Why the study?
Myocardial fibrosis impairs cardiac function and causes adverse events, making accurate characterization with CMR and emerging techniques like T1 mapping relevant for patient monitoring and management.
CMR, including emerging techniques like longitudinal relaxation time mapping, offers significant potential for characterizing myocardial fibrosis and guiding therapeutic management in cardiomyopathies.
Should not yet change practice in cardiomyopathies; leaves open prospective validation of longitudinal relaxation time mapping.
Diffuse interstitial or replacement myocardial fibrosis are common features of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiac magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial T 1 mapping is an emerging technique that could improve CMR’s diagnostic accuracy especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and the therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.
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Mewton et al. (2011) conducted a review in Myocardial fibrosis in cardiomyopathies. Cardiovascular magnetic resonance (CMR) was evaluated. Cardiovascular magnetic resonance, particularly longitudinal relaxation time mapping, characterizes replacement and diffuse interstitial myocardial fibrosis to guide therapeutic management.