Abstract The synthesis of reactive compounds through functional group transformations of amino acids holds immense importance as the products serve as unique starting materials in the assembly of new classes of peptides, peptoids, and peptide mimics. Isocyanates derived from amino acids are a versatile class of compounds that can serve as key starting materials for the synthesis of a wide array of novel structures. The incorporation of the isocyanato group into amino acids has been the focus of research for a long time, leading to the development of numerous original methods for this purpose. In addition, various synthetic modifications and stabilized derivatives of isocyanates of amino acids have been reported. This review offers a comprehensive account of the reagents and synthetic methodologies developed to obtain isocyanates from amino acids, as well as the approaches employed to stabilize these reactive compounds.
Kumar et al. (Thu,) studied this question.