August 1, 2004Journal of the American Society of Nephrology
Renal Function, Digoxin Therapy, and Heart Failure Outcomes
Why the study?
Does digoxin efficacy differ by level of renal function, and how does GFR affect mortality in outpatients with systolic heart failure?
Population
6800 outpatients with systolic heart failure
Design
Cohort
Follow-up
mean, 3 yr
Authors
Discussion
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Member takes
Implication
eGFR <50 ml/min/1.73 m² associated with higher mortality in systolic HF outpatients without modifying digoxin effect; leaves open renal-stratified dosing trials.
Structured PICO
Does digoxin efficacy differ by level of renal function, and how does GFR affect mortality in outpatients with systolic heart failure?
P
Population
6800 outpatients with systolic heart failure
I
Intervention
Digoxin
O
Outcome
All-cause mortalityhard clinical
Renal dysfunction (eGFR <50) is strongly associated with increased mortality in stable systolic heart failure, but does not alter the efficacy of digoxin.
Cite This Study
Shlipak et al. (2004) studied this question.