METTL3-mediated m6A modification of lncRNA MALAT1 promotes colorectal cancer progression by activating the NF-κB signaling pathway

Key Points

• The aim is to understand how METTL3-mediated m6A modifications affect colorectal cancer progression.
• Investigated the role of METTL3 in m6A modification of MALAT1 and its impact on NF-κB signaling.
• Utilized experimental models to elucidate the regulatory axis in colorectal cancer.
• Provided insights into potential therapeutic strategies targeting METTL3.
• Identified METTL3 as a key mediator in promoting colorectal cancer progression via MALAT1 and NF-κB regulation.
• Demonstrated that m6A modifications of MALAT1 significantly enhance NF-κB signaling activity.