Sulfonamide DPA-Based Mononuclear Cobalt(II) Complexes: Evaluation of ROS-Driven Cytotoxicity.

Key Points

• The aim is to evaluate the cytotoxicity of sulfonamide DPA-based cobalt(II) complexes against breast cancer cells.
• Evaluation of complex 2's activity against MDA-MB-231 and MCF-7 cell lines
• Measurement of IC50 values for cytotoxicity
• Analysis of reactive oxygen species generation as a mechanism of action.
• Complex 2 shows IC50 values of 95.9 µM against MDA-MB-231 cells and 91.3 µM against MCF-7 cells.
• The enhanced activity of complex 2 is attributed to increased reactive oxygen species generation.