Controlling the regioselectivity in C-H functionalization is a challenging issue in organic synthesis. Typically, the specific electronic and/or steric character of the substrate leads to intrinsic site selectivity in C-H functionalization. While enhancing intrinsic site selectivity is relatively straightforward, altering and reversing high selectivity is challenging. By the use of a designed ligand for an iridium catalyst, the normally preferred
Qin et al. (Mon,) studied this question.