Biomimetic characterization by micro-computed tomography (μCT) of 3D hollow fibre membrane network bioreactors for tissue engineering

Key Points

• The aim is to characterize hollow fiber membrane bioreactors for their performance in tissue engineering applications.
• Utilized micro-computed tomography (μCT) for detailed imaging of hollow fiber networks.
• Evaluated the transport dynamics of nutrients, gases, and metabolites within the bioreactors.
• Assessed the effectiveness of bioreactors in supporting high-density mammalian cell culture.
• Demonstrated superior transport of nutrients and gases compared to traditional bioreactor designs.
• High cell density was maintained effectively within the hollow fiber network, outperforming standard systems.
• Characterization revealed unique structural properties beneficial for tissue engineering applications.