Does CROT deficiency reduce vascular calcification in LDL receptor-deficient mice?
CROT is identified as a novel contributing factor in vascular calcification, suggesting its inhibition could serve as a potential antifibrocalcific therapy.
OBJECTIVE: deficiency in LDL (low-density lipoprotein) receptor-deficient mice reduced aortic and carotid artery calcification without altering bone density or liver and plasma cholesterol and triglyceride concentrations. CONCLUSIONS: CROT is a novel contributing factor in vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction, as such CROT inhibition has strong potential as an antifibrocalcific therapy.
Okui et al. (Thu,) studied this question.