Does higher cardiorespiratory fitness modify the association between polygenic risk score and CSF biomarkers of Alzheimer disease in a late-middle-aged cohort?
Higher cardiorespiratory fitness attenuates the adverse influence of genetic vulnerability on CSF biomarkers of Alzheimer disease in late-middle-aged individuals.
OBJECTIVE: is associated with CSF biomarkers of Alzheimer disease (AD) pathology and whether higher cardiorespiratory fitness (CRF) modifies the association between the PRS and CSF biomarkers. METHODS: ratios were computed. CRF was estimated from a validated equation incorporating sex, age, body mass index, resting heart rate, and self-reported physical activity. Covariate-adjusted regression analyses were used to test for associations between the PRS and CSF biomarkers. In addition, by including a PRS×CRF term in the models, we examined whether these associations were modified by CRF. RESULTS: = 0.001). Specifically, the association between the PRS and these CSF biomarkers was diminished in those with higher CRF. CONCLUSIONS: In a late-middle-aged cohort, CRF attenuates the adverse influence of genetic vulnerability on CSF biomarkers. These findings support the notion that increased cardiorespiratory fitness may be beneficial to those at increased genetic risk for AD.
Schultz et al. (Sat,) studied this question.