June 6, 2019Open Access

Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner

AJAjeetha JosephrajanUniversity of Southern Denmark AHAnn V. HertzelUniversity of Minnesota System EBEllie K. BohmUniversity of Minnesota

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Abstract

knockout mice. In addition, blocking SIRT1 by EX527 attenuated secretion while activating SIRT1 by resveratrol-potentiated secretion. These studies suggest that FABP4 secretion from adipocytes is regulated by SIRT1 and requires early autophagic components.

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Josephrajan et al. (Thu,) studied this question.

synapsesocial.com/papers/6a0386be64156e454985fba7 https://doi.org/https://doi.org/10.2337/db18-1367

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