ABSTRACT The genus Nepeta encompasses over 296 accepted species widely distributed across Asia, Europe, and North Africa. This review offers a foundation for future pharmacological, phytochemical, and clinical investigations into this underexplored genus. This review critically examines studies published between 2021 and 2025, focusing on the phytochemical diversity, pharmacological properties, and medicinal relevance of Nepeta species. The databases, such as Scifinder, PubMed, PubChem, Taylor & Francis Online, ScienceDirect, Springer, and Google Scholar, were used for the collection of research articles about the focused genus, Nepeta . In the current study, numerous bioactive compounds, already reported, have been documented, including nepetalactones, iridoid glycosides, flavonoids, and terpenoids, which are responsible for a broad spectrum of biological activities. These include antioxidant, anticancer, anti‐inflammatory, and enzyme inhibitory effects as validated through in vitro and in vivo models. The therapeutic applications of Nepeta extracts and essential oils are further supported by ethnobotanical records and pharmacological evidence, underscoring the potential of Nepeta species in drug discovery and integrative medicine. Despite promising outcomes, the literature reveals a lack of clinical studies, standardized assays, and comprehensive toxicity profiles, which are essential for the translational development of Nepeta ‐derived therapeutics.
Ali et al. (Fri,) studied this question.