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May 14, 2026Physiology

Cerebrovascular hemodynamic responses differ during aerobic versus resistance exercise in young healthy adults

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Why the study?

Aerobic and resistance exercise benefit brain health, but their differing acute cerebrovascular hemodynamic responses during exercise remained to be compared.

Does aerobic exercise elicit different acute cerebrovascular hemodynamic responses compared to resistance exercise in young healthy adults?

Population

15 young, healthy adults

Comparison

Aerobic exercise (60% VO2 max) vs leg press resistance exercise (65% 1-RM)

Design

Crossover study with separate visits

Key result

Aerobic exercise elicited larger increases in carotid pulsatility index (∆+1.80 vs ∆+0.95 au, p=0.014) and pulse pressure compared to resistance exercise, while intracranial responses were similar.

Authors

KRKrista ReedSRSpencer RomanowskiAJAbigail Johnson

Discussion

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Member takes

Overview

Acute differences in cerebrovascular pulsatility between exercise modes should not yet guide clinical recommendations; extends mechanistic understanding but requires longitudinal studies to confirm brain health implications.

Key Points

  • This study aims to compare acute cerebrovascular hemodynamic responses during aerobic and resistance exercise.
  • 15 young healthy adults participated (age: 27±6 years; BMI: 24±2.2 kg/m2; n=8 females)
  • Cerebrovascular measures were taken at rest and during aerobic exercise (60% VO2 max) and leg press resistance exercise (65% 1-RM)
  • Doppler ultrasound and tonometry assessed middle cerebral artery pulsatility index, carotid pulsatility index, carotid pulse pressure, and β-stiffness.
  • Aerobic exercise elicited larger increases in carotid pulsatility index (∆+1.80±0.87 au, p=0.014) compared to resistance exercise (∆+0.95±0.85 au)
  • Carotid pulse pressure increased more during aerobic exercise (∆+42±22 mmHg, p=0.04) than resistance exercise (∆+16±15 mmHg)
  • Pulsatile damping was greater during aerobic exercise (∆+0.89±0.64 au, p=0.04) compared to resistance exercise (∆+0.27±0.54 au)

Structured PICO

Does aerobic exercise elicit different acute cerebrovascular hemodynamic responses compared to resistance exercise in young healthy adults?

P
Population
15 young, healthy adults (age: 27±6 years; BMI: 24±2.2 kg/m2; n=8 females)
I
Intervention
Aerobic exercise (AE; 60% VO2 max)
C
Comparator
Leg press resistance exercise (RE; 65% 1-RM) on separate visits
O
Outcome
Acute cerebrovascular hemodynamic responses including middle cerebral artery (MCA) and carotid pulsatility index (PI), pulsatile damping, carotid pulse pressure (PP), and β-stiffnesssurrogate

Main Result

Absolute Event Rate: 1.8% vs 0.95%

p-value: p=0.014

Aerobic exercise elicits greater extracranial pulsatile hemodynamics and pulsatile damping than resistance exercise, though intracranial hemodynamic responses remain similar, suggesting both provide beneficial cerebrovascular stimuli.

Cite This Study

Reed et al. (2026) studied Healthy adults (n=15). Aerobic exercise vs. Resistance exercise (65% 1-RM leg press) was evaluated on Change in carotid pulsatility index (PI) (p=0.014). Aerobic exercise elicited larger increases in carotid pulsatility index (∆+1.80 vs ∆+0.95 au, p=0.014) and pulse pressure compared to resistance exercise, while intracranial responses were similar.

synapsesocial.com/papers/6a0567fda550a87e60a20494https://doi.org/10.1152/physiol.2026.41.s1.2299323
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