Key result
LAA occlusion and excision provide alternative thromboembolism prophylaxis for AF patients contraindicated for anticoagulation.
Why the study?
Anticoagulants reduce thrombus formation in atrial fibrillation but may be contraindicated, prompting the study and clinical utility of left atrial appendage excision or occlusion for thromboembolism prophylaxis.
Left atrial appendage occlusion or excision provides an alternative for thromboembolism prophylaxis in patients with atrial fibrillation who have contraindications to anticoagulants.
May support LAA occlusion/excision for thromboembolism prophylaxis in anticoagulant-contraindicated AF; leaves open need for randomized confirmation.
In patients with atrial fibrillation, the left atrial appendage may serve as the site of thrombus formation due to stasis that occurs within the appendage because of its shape and trabeculations. Although thrombus formation can be reduced by using anticoagulants, this may be contraindicated in some patients. The need for a better alternative treatment prompted the study of left atrial appendage occlusion for thromboembolism prophylaxis. Due to this, procedures that excise or occlude the left atrial appendage have gained attention because of their ability to prevent thromboembolic events. This article provides a comprehensive review of the left atrial appendage and its associated procedures' clinical utility.
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Sulague et al. (2023) conducted a review in Atrial fibrillation. Left atrial appendage occlusion or excision was evaluated. Left atrial appendage occlusion and excision procedures provide an alternative for thromboembolism prophylaxis in patients with atrial fibrillation who have contraindications to anticoagulants.
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