Sustained obesity in sheep induced biatrial endocardial remodeling, increased atrial fibrosis (p=0.03), and resulted in more episodes (p=0.02) and greater cumulative duration (p=0.02) of AF.
Does sustained obesity induce electrophysiological and structural remodeling of the atria increasing vulnerability to AF in a sheep model?
Sustained obesity in a sheep model leads to significant biatrial endocardial remodeling, epicardial fat infiltration, and increased propensity for atrial fibrillation.
BACKGROUND: Obesity and atrial fibrillation (AF) are public health issues with significant consequences. OBJECTIVES: This study sought to delineate the development of global electrophysiological and structural substrate for AF in sustained obesity. METHODS: Ten sheep fed ad libitum calorie-dense diet to induce obesity over 36 weeks were maintained in this state for another 36 weeks; 10 lean sheep with carefully controlled weight served as controls. All sheep underwent electrophysiological and electroanatomic mapping; hemodynamic and imaging assessment (echocardiography and dual-energy x-ray absorptiometry); and histology and molecular evaluation. Evaluation included atrial voltage, conduction velocity (CV), and refractoriness (7 sites, 2 cycle lengths), vulnerability for AF, fatty infiltration, atrial fibrosis, and atrial transforming growth factor (TGF)-β1 expression. RESULTS: Compared with age-matched controls, chronically obese sheep demonstrated greater total body fat (p 0.8) or ERP heterogeneity (p > 0.3). Obesity was associated with more episodes (p = 0.02), prolongation (p = 0.01), and greater cumulative duration (p = 0.02) of AF. Epicardial fat infiltrated the posterior LA in the obese group (p < 0.001), consistent with reduced endocardial voltage in this region. Atrial fibrosis (p = 0.03) and TGF-β1 protein (p = 0.002) were increased in the obese group. CONCLUSIONS: Sustained obesity results in global biatrial endocardial remodeling characterized by LA enlargement, conduction abnormalities, fractionated electrograms, increased profibrotic TGF-β1 expression, interstitial atrial fibrosis, and increased propensity for AF. Obesity was associated with reduced posterior LA endocardial voltage and infiltration of contiguous posterior LA muscle by epicardial fat, representing a unique substrate for AF.
Mahajan et al. (Mon,) conducted a other in Obesity and Atrial Fibrillation (n=20). Sustained obesity (calorie-dense diet) vs. Lean sheep (controlled weight) was evaluated on Electrophysiological, electroanatomic, and structural remodeling. Sustained obesity in sheep induced biatrial endocardial remodeling, increased atrial fibrosis (p=0.03), and resulted in more episodes (p=0.02) and greater cumulative duration (p=0.02) of AF.