Why the study?
Does acute low-flow ischemia lead to the translocation of GLUT-4 and GLUT-1 to the sarcolemma in a canine model?
Population
Canine model
Comparison
Acute low-flow ischemia vs Nonischemic region
Design
Preclinical
Key result
Acute low-flow ischemia in a canine model increased sarcolemma content of GLUT-4 (15% to 30%, P<0.02) and GLUT-1 (41% to 58%, P<0.03) compared with nonischemic regions.
Authors
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Hypothesis-generating for ischemia-induced myocardial glucose uptake; leaves open human translation.
Does acute low-flow ischemia lead to the translocation of GLUT-4 and GLUT-1 to the sarcolemma in a canine model?
Absolute Event Rate: 30% vs 15%
p-value: p=<0.02
Acute low-flow ischemia induces the translocation of both GLUT-1 and GLUT-4 to the sarcolemma, facilitating ischemia-mediated myocardial glucose uptake in vivo.
Young et al. (1997) studied Myocardial ischemia. Low-flow ischemia vs. Nonischemic region was evaluated on Sarcolemma content of GLUT-4 (p=<0.02). Acute low-flow ischemia in a canine model increased sarcolemma content of GLUT-4 (15% to 30%, P<0.02) and GLUT-1 (41% to 58%, P<0.03) compared with nonischemic regions.