Influence of circadian alignment and sleep timing variability on sex-specific inflammatory markers in healthy adults

Disturbances to sleep and the circadian timing system have significant implications for cardiovascular health. Inflammatory markers have been shown to be predictive of CVD risk; however, the extent to which circadian disturbances and sleep timing contribute to sex-specific markers of inflammation is unclear. In this study, we leverage in-laboratory and outpatient biobehavioral data collection to show that the relationships between circadian disruptions and/or sleep timing variability may be differentially linked to inflammatory markers by sex.