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Objective: We aimed to comprehensively assess the accuracy of patient-derived organoids to recapitulate the genomic features of patient tumors, and to quantify the reliability of patient-derived organoid-based drug screening, by pooling the available evidence and the validation using our patient-derived lung cancer organoids (LCOs). Methods: A comprehensive online search was conducted to identify eligible studies. A total of 20 LCOs harvested from surgical samples were also established as our internal validation cohort, with whole-exome sequencing and transcriptomic sequencing performed, respectively. Pooled concordance in genetic profiles between LCOs and original tumors was calculated, along with the overall accuracy of LCOs for drug profiling. Results: = 0.231). Conclusions: Our study indicates that LCOs can stably recapitulate the genomic features of patient tumors irrespective of histologic heterogeneity and be a promising precision medicine tool for anticancer drug screening or for predicting drug responses.
Chen et al. (Mon,) studied this question.