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The aim is to illustrate the presentation and management of idiopathic acquired hemophilia A in an elderly patient.

May 17, 2026CureusOpen Access

Idiopathic Acquired Hemophilia A With High-Titer Factor VIII Inhibitor in an Elderly Patient: A Case Report

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The aim is to illustrate the presentation and management of idiopathic acquired hemophilia A in an elderly patient.
Case report of an 84-year-old woman with spontaneous bruising and prolonged aPTT.
Patient underwent laboratory tests revealing severe normocytic anemia and high-titer factor VIII inhibitor.
Treatment included high-dose prednisone and weekly rituximab.
Initial tests showed factor VIII activity <5% and a high-titer inhibitor of 470 Bethesda Units.
Following treatment, the patient exhibited clinical improvement, with normalization of aPTT and recovery of factor VIII activity.
Disappearance of the factor VIII inhibitor was observed during follow-up.

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Case report reveals clinical improvement following immunosuppressive therapy in an elderly patient with spontaneous bleeding.

Morris et al. (2026) studied this question.

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