Stevioside extends the healthspan and improves Alzheimer's disease and increases oxidative stress resistance via the mitochondrial unfolded protein response

Key Points

• The aim is to investigate the effects of stevioside on healthspan and its role in Alzheimer's disease and oxidative stress resistance.
• Intervention with stevioside to assess its impact on healthspan and Alzheimer's symptoms.
• Evaluation of oxidative stress resistance mechanisms through the mitochondrial unfolded protein response.
• Stevioside significantly extends healthspan and improves symptoms associated with Alzheimer's disease.
• Increased resistance to oxidative stress was observed, linked to activation of the mitochondrial unfolded protein response mediated by ATFS-1.