Key result
Inspiratory muscle training improves peak VO2 by ~2.8 ml/kg/min and 6-minute walk distance in HFpEF.
Why the study?
There is a paucity of data on the role of inspiratory muscle training in improving cardiorespiratory fitness in patients with HFpEF.
Does inspiratory muscle training improve peak oxygen consumption and six-minute walk distance in patients with stable HFpEF?
Population
Stable HFpEF patients across three RCTs and one prospective study
Comparison
Inspiratory muscle training vs standard care
Design
Meta-analysis of three RCTs and one prospective study
Follow-up
12 to 24 weeks
Authors
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Supports adding IMT to HFpEF care for exercise gains; extends prior trials via Level 1 meta-analysis.
Meta-Analysis
Does inspiratory muscle training improve peak oxygen consumption and six-minute walk distance in patients with stable HFpEF?
Effect estimate: MD 2.82 ml/kg/min (95% CI 1.90-3.74)
p-value: p=<0.00001
Inspiratory muscle training significantly improves cardiorespiratory fitness, including peak VO2 and 6-minute walk distance, in patients with stable HFpEF.
Baral et al. (2020) conducted a meta-analysis in Heart failure with preserved ejection fraction (HFpEF). Inspiratory muscle training (IMT) vs. Standard care (SC) was evaluated on Peak oxygen consumption (Peak VO2) at 12 weeks (MD 2.82 ml/kg/min, 95% CI 1.90-3.74, p=<0.00001). Inspiratory muscle training significantly improved peak oxygen consumption (MD 2.82 ml/kg/min; 95% CI 1.90-3.74; P<0.00001) and 6-minute walk distance compared to standard care in HFpEF patients.