January 15, 1996Circulation
Platelet Function in Acute Myocardial Infarction Treated With Direct Angioplasty
Key result
Direct PTCA for acute myocardial infarction caused a transient decrease in platelet fibrinogen receptor activity and P-selectin expression at 8 hours (P<0.01), followed by a subsequent increase.
Why the study?
Does direct PTCA alter platelet function and activation over time in patients with anterior AMI compared to elective balloon angioplasty?
Population
15 patients with anterior acute myocardial infarction (AMI)
Comparison
Direct percutaneous transluminal coronary… vs 15 patients with stable coronary heart disease…
Design
Cohort
Follow-up
48 hours
Authors
Discussion
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Implication
Direct PTCA in AMI associates with biphasic platelet changes; leaves open optimal antiplatelet timing for prospective trials.
Study Design
Type
Observational (n=30)
Structured PICO
Does direct PTCA alter platelet function and activation over time in patients with anterior AMI compared to elective balloon angioplasty?
P
Population
15 patients with anterior acute myocardial infarction (AMI)
I
Intervention
Direct percutaneous transluminal coronary angioplasty (PTCA)
C
Comparator
15 patients with stable coronary heart disease undergoing elective balloon angioplasty
O
Outcome
Fibrinogen receptor function and surface expression of P-selectin on platelets measured by flow cytometry before and 4, 8, 24, and 48 hours after recanalizationsurrogate
Main Result
p-value: p=< .01
Direct PTCA in AMI induces a transient apparent deactivation of circulating platelets followed by increased activation, underscoring the need for novel antiplatelet strategies.
Cite This Study
Gawaz et al. (1996) conducted an observational in Acute Myocardial Infarction (n=30). Direct percutaneous transluminal coronary angioplasty (PTCA) vs. Elective balloon angioplasty was evaluated on Fibrinogen receptor function and surface expression of P-selectin on platelets (p=< .01). Direct PTCA for acute myocardial infarction caused a transient decrease in platelet fibrinogen receptor activity and P-selectin expression at 8 hours (P<0.01), followed by a subsequent increase.