Key result
Post-procedure QFR strongly predicted 5-year MACCEs in CTO patients (AUC 0.80; 95% CI 0.77-0.83; P<0.001), with event rates of 63.9% in the low QFR tertile versus 12.6% in the high QFR tertile.
Why the study?
QFR helps assess revascularization benefits, but whether post-procedure QFR measurements can predict long-term outcomes after CTO PCI required evaluation.
Does post-procedure QFR predict long-term MACCEs in patients undergoing PCI for CTO?
Cohort (n=616)
Does post-procedure QFR predict long-term MACCEs in patients undergoing PCI for CTO?
Effect estimate: AUC 0.80 (95% CI 0.77-0.83)
Absolute Event Rate: 63.9% vs 12.6%
p-value: p=<0.001
Post-procedure QFR assessment is a strong predictor of 5-year MACCEs in patients undergoing PCI for chronic total occlusion.
No takes yet. Share an insight, caveat, or question.
Xin et al. (2025) conducted a cohort in Coronary chronic total occlusion (CTO) (n=616). Post-procedure Quantitative Flow Ratio (QFR) assessment vs. High QFR (≥ 0.88) was evaluated on Major Adverse Cardiac and Cerebrovascular Events (MACCEs) (AUC 0.80, 95% CI 0.77-0.83, p=<0.001). Post-procedure QFR strongly predicted 5-year MACCEs in CTO patients (AUC 0.80; 95% CI 0.77-0.83; P<0.001), with event rates of 63.9% in the low QFR tertile versus 12.6% in the high QFR tertile.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: