Key result
Higher LDL particle number (1680 vs 1501 nmol/L) and small LDL levels (7 vs 0 mg%) were significantly associated with incident myocardial infarction and angina among older women.
Why the study?
Are lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy associated with incident coronary heart disease?
Cohort (n=683)
Are lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy associated with incident coronary heart disease?
Small LDL, LDL particle size, and LDL particle number measured by NMR spectroscopy are associated with incident coronary heart disease in older women.
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Does not support routine NMR lipoprotein testing in older women; leaves open incremental value over standard lipids for CHD prediction.
Kuller et al. (2002) conducted a cohort in Coronary Heart Disease (n=683). Lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy vs. Healthy participants was evaluated on Incident myocardial infarction (MI) and angina. Higher LDL particle number (1680 vs 1501 nmol/L) and small LDL levels (7 vs 0 mg%) were significantly associated with incident myocardial infarction and angina among older women.
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