Key result
Chronic acquired demyelinative neuropathy is characterized by multifocal slowing of nerve conduction and conduction block, whereas familial demyelinative neuropathy shows uniform conduction slowing.
Why the study?
Do electrodiagnostic studies differentiate between chronic acquired and familial demyelinative neuropathies?
Observational (n=58)
Do electrodiagnostic studies differentiate between chronic acquired and familial demyelinative neuropathies?
Electrodiagnostic studies can reliably distinguish between chronic acquired (multifocal slowing, conduction block) and familial (uniform slowing) demyelinative neuropathies.
Electrodiagnostic patterns may aid differentiation of acquired versus familial demyelinating neuropathies; leaves open need for prospective validation.
We compared the electrodiagnostic studies of 40 patients with chronic acquired demyelinative neuropathy and 18 patients with familial demyelinative neuropathy. Patients with acquired neuropathy had differential slowing of conduction velocity when distal latencies were compared with more proximal conduction velocities in the same nerve, when equivalent segments of different nerves were compared, and when dispersion of compound motor action potentials was examined. Conduction block was noted in some patients. Patients with familial disease had uniform conduction slowly of all nerve segments, and conduction block was not seen. Chronic acquired demyelinative neuropathy is characterized by multifocal slowing of nerve conduction, whereas familial demyelinative neuropathy is characterized by uniform conduction slowing.
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Lewis et al. (1982) conducted an observational in Chronic acquired and familial demyelinative neuropathies (n=58). Chronic acquired demyelinative neuropathy vs. Familial demyelinative neuropathy was evaluated on Electrodiagnostic study characteristics (conduction velocity slowing patterns). Chronic acquired demyelinative neuropathy is characterized by multifocal slowing of nerve conduction and conduction block, whereas familial demyelinative neuropathy shows uniform conduction slowing.
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