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November 29, 2006Cardiovascular Research

Surgical animal models of heart failure related to coronary heart disease

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Key result

Surgical animal models based on narrowing or occlusion of coronary arteries are indispensable for investigating the pathogenesis of coronary heart disease-related heart failure and developing therapies.

Population

Laboratory animals used for modeling heart failure related to coronary heart disease

Design

Review

Authors

RKRainer KlockeTH Köln - University of Applied SciencesWTWen TianFirst Hospital of Lanzhou UniversityMKMichael KuhlmannPaderborn University

Discussion

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Implication

Supports coronary occlusion models for HF research; leaves open optimal species selection and clinical translation.

Structured PICO

P
Population
Laboratory animals used for modeling heart failure related to coronary heart disease
I
Intervention
Surgical narrowing or occlusion of coronary arteries (models of myocardial infarction, cardiac ischemia/reperfusion injury, or chronic cardiac ischemia)

This review outlines surgical animal models for coronary heart disease-related heart failure, emphasizing the impact of species, strain, and gender on pathophysiology.

Cite This Study

Klocke et al. (2006) conducted a review in Heart failure related to coronary heart disease. Surgical animal models was evaluated. Surgical animal models based on narrowing or occlusion of coronary arteries are indispensable for investigating the pathogenesis of coronary heart disease-related heart failure and developing therapies.

synapsesocial.com/papers/6a0fe14e2badbc352afee064https://doi.org/10.1016/j.cardiores.2006.11.026

Topics

Heart failureHFrEF treatment
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