The investigational Octaray catheter increased electrogram acquisition rate compared to the standard Pentaray catheter (814 vs. 148 EGM/min, P=0.02) in a swine model of healed infarction.
Does an investigational multielectrode mapping catheter with more, smaller, and closely spaced electrodes improve mapping efficiency and EGM density compared to a standard catheter in a swine model of healed infarction?
A novel multielectrode mapping catheter with 48 small, closely spaced electrodes significantly increases mapping speed, EGM density, and the ability to recognize low-amplitude near-field EGMs in a swine model of healed infarction.
Absolute Event Rate: 814% vs 148%
p-value: p=0.02
Abstract Aims Multielectrode mapping catheters can be advantageous for identifying surviving myocardial bundles in scar. This study aimed to evaluate the utility of a new multielectrode catheter with increased number of small and closely spaced electrodes for mapping ventricles with healed infarction. Methods and results In 12 swine (four healthy and eight with infarction), the left ventricle was mapped with investigational (OctarayTM) and standard (PentarayTM) multielectrode mapping catheters. The investigational catheter has more electrodes (48 vs. 20), each with a smaller surface area (0.9 vs. 2.0 mm2) and spacing is fixed at 2 mm (vs. 2–6–2 mm). Electrogram (EGM) characteristics, mapping efficiency and scar description were compared between the catheters and late gadolinium enhancement (LGE). Electrogram acquisition rate was faster with the investigational catheter (814 ± 126 vs. 148 ± 58 EGM/min, P = 0.02) resulting in higher density maps (38 ± 10.3 vs. 10.1 ± 10.4 EGM/cm2, P = 0.02). Bipolar voltage amplitude was similar between the catheters in normal and infarcted myocardium (P = 0.265 and P = 0.44) and the infarct surface area was similar between the catheters (P = 0.12) and corresponded to subendocardial LGE. The investigational catheter identified a higher proportion of near-field local abnormal ventricular activities within the low-voltage area (53 ± 16% vs. 34 ± 16%, P = 0.03) that were considered far-field EGMs by the standard catheter. The investigational catheter was also advantageous for mapping haemodymically non-tolerated ventricular tachycardias due to its higher acquisition rate (P 0.001). Conclusion A novel multielectrode mapping catheter with higher number of small, and closely spaced electrodes increases the mapping speed, EGM density and the ability to recognize low amplitude near-field EGMs in ventricles with healed infarction.
Barkagan et al. (Thu,) conducted a other in Healed infarction (n=12). Investigational multielectrode mapping catheter (Octaray) vs. Standard multielectrode mapping catheter (Pentaray) was evaluated on Electrogram acquisition rate (EGM/min) (p=0.02). The investigational Octaray catheter increased electrogram acquisition rate compared to the standard Pentaray catheter (814 vs. 148 EGM/min, P=0.02) in a swine model of healed infarction.