The AGTM235T gene polymorphism was significantly associated with essential hypertension (OR 1.57%), but none of the studied polymorphisms influenced the blood pressure-lowering efficacy of ramipril.
Case-Control (n=166)
Yes
Do AGT and ACE gene polymorphisms associate with essential hypertension and affect the blood pressure-lowering efficacy of ramipril?
While the AGTM235T polymorphism is associated with essential hypertension, AGT and ACE gene polymorphisms do not appear to influence the clinical efficacy of ramipril.
Effect estimate: OR 1.57% (95% CI 1.01 - 2.44)
p-value: p=0.045
BACKGROUND: Hypertension, one of the most important risk factors for premature cardiovascular disease, is a major worldwide public health problem. Angiotensin-1-converting enzyme (ACE) and angiotensinogen (AGT) gene polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these gene polymorphisms in an adult population with and without essential hypertension. Furthermore, we evaluated the effect of ACE and AGT gene polymorphisms on ramipril treatment efficacy in the hypertensive patients. METHODS: A total of 166 adults (83 hypertensives and 83 normotensives) were involved in the study and genotyped for AGTM235T (rs699), AGTT174M (rs4762) and ACEI/D (rs1799752) gene polymorphisms. RESULTS: The genotype and allele distribution of the AGTM235T variant significantly differed between hypertensives and normotensives odds ratio (OR) = 1.57% (T vs M allele), 95% confidence intervals (CIs): 1.01 - 2.44; p=0.045 for hypertensives. However, none of the 3 studied Simple Nucleotide Polymorphisms were associated with the blood pressure-lowering response to ramipril. CONCLUSION: These results suggest that AGTM235T gene polymorphism is associated with essential hypertension. However, none of the AGTM235T, AGTT174M and ACEI/D gene polymorphisms influenced ramipril effectiveness.
Kolovou et al. (Tue,) conducted a case-control in Essential Hypertension (n=166). Ramipril vs. Normotensive controls was evaluated on Association of AGTM235T variant (T vs M allele) with essential hypertension (OR 1.57%, 95% CI 1.01 - 2.44, p=0.045). The AGTM235T gene polymorphism was significantly associated with essential hypertension (OR 1.57%), but none of the studied polymorphisms influenced the blood pressure-lowering efficacy of ramipril.
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