Concomitant TAVI and complex/high-risk PCI yielded similar primary outcomes to staged procedures (p=0.98) but increased secondary adverse events (25.8% vs 17.4%; p=0.014).
Cohort (n=519)
Does concomitant TAVI and complex/high-risk PCI improve outcomes compared to a staged approach in patients with severe aortic stenosis?
In patients requiring both TAVI and complex/high-risk PCI, a staged approach may be preferable as concomitant procedures are associated with higher rates of procedural adverse events.
p-value: p=0.98
BACKGROUND: There is a lack of evidence to guide treatment of patients with a concomitant indication for transcatheter aortic valve implantation (TAVI) and complex, high-risk percutaneous coronary intervention (PCI). AIMS: We aimed to assess different strategies of PCI timing in this high-risk TAVI cohort. METHODS: The ASCoP registry retrospectively included patients with a clinical indication for both TAVI and PCI with at least 1 criterion of complex or high-risk PCI. The primary endpoint was a composite of all-cause death and unplanned rehospitalisation for cardiovascular causes. The secondary endpoint was a composite of all-cause death, stroke, acute myocardial infarction, major bleeding, major vascular complication and unplanned revascularisation. Multivariable analysis was used to adjust for possible confounders. RESULTS: A total of 519 patients were included: 363 (69.9%) underwent staged procedures and 156 (30.1%) concomitant TAVI and PCI. After 441 (interquartile range 182-824) days, the primary endpoint occurred in 151 (36.5%) cases, without any significant difference between the 2 groups (p=0.98), while the secondary endpoint occurred more frequently in the concomitant group (n=36 25.8% vs n=57 17.4%; p=0.014). CONCLUSIONS: In patients undergoing TAVI and complex/high-risk PCI, a concomitant strategy is associated with a higher rate of adverse events and increased procedural risk. (ClinicalTrials.gov: NCT05750927).
Montalto et al. (Tue,) conducted a cohort in Severe aortic stenosis with concomitant indication for TAVI and complex, high-risk PCI (n=519). Concomitant TAVI and PCI vs. Staged TAVI and PCI was evaluated on Composite of all-cause death and unplanned rehospitalisation for cardiovascular causes (p=0.98). Concomitant TAVI and complex/high-risk PCI yielded similar primary outcomes to staged procedures (p=0.98) but increased secondary adverse events (25.8% vs 17.4%; p=0.014).