What question did this study set out to answer?

This study aimed to investigate how SARS-CoV-2 vaccination affects cell-mediated immunity in inflammatory bowel disease patients and its relationship with IgG antibody levels.

May 25, 2026GastroHepOpen Access

Immunosuppressed Patients With Inflammatory Bowel Disease Have Reduced Cell‐Mediated Immunity but Maintain Normal Humoral Immunity in Response to SARS‐CoV‐2 Vaccination

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Authors

MPMagno Luís Costa PereiraUniversidade do Estado do Rio de Janeiro SAS Galdino de AzevedoUniversidade do Estado do Rio de Janeiro ILIsadora Schmukler de LimaUniversidade Federal do Rio de Janeiro

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Implication

Cross-sectional study examines immune responses in inflammatory bowel disease patients following SARS-CoV-2 vaccination, suggesting altered cellular immunity.

Key Points

This study aimed to investigate how SARS-CoV-2 vaccination affects cell-mediated immunity in inflammatory bowel disease patients and its relationship with IgG antibody levels.
Cross-sectional observational study with 138 patients split between Crohn's disease and ulcerative colitis.
Patients categorized into nonimmunosuppressed, corticosteroid or azathioprine users, and biological agent users.
Blood samples analyzed for IgG antibodies against the SARS-CoV-2 spike protein and antigen-specific cytokine levels.
All tested cytokines significantly increased after stimulation with the SARS-CoV-2 spike protein, except IL-4 and IL-17 in patients on biologicals.
Nonimmunosuppressed patients exhibited higher levels of TNF-α, IL-6, and IL-10 compared to the other groups.
A positive correlation was found between interferon gamma (IFN-γ) levels and antibody titers.

Cite This Study

Pereira et al. (2026) studied this question.

synapsesocial.com/papers/6a13e7e80e02ee3982d328ec https://doi.org/10.1155/ygh2/2615789

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Implication

Cross-sectional study examines immune responses in inflammatory bowel disease patients following SARS-CoV-2 vaccination, suggesting altered cellular immunity.

Immunosuppressed Patients With Inflammatory Bowel Disease Have Reduced Cell‐Mediated Immunity but Maintain Normal Humoral Immunity in Response to SARS‐CoV‐2 Vaccination

Discussion

Member takes

Implication

Key Points

Cite This Study

Immunosuppressed Patients With Inflammatory Bowel Disease Have Reduced Cell‐Mediated Immunity but Maintain Normal Humoral Immunity in Response to SARS‐CoV‐2 Vaccination

Discussion

Member takes

Implication

Key Points

Cite This Study

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