Key result
Analog systemic filling and venous return pressures with echo predict stroke volume changes after PLR.
Observational
Yes
May aid fluid responsiveness assessment at bedside; hypothesis-generating and requires validation before clinical use.
The analog mean systemic filling pressure and the pressure gradient for venous return combined with echocardiography predict continuous changes in stroke volume following a passive leg raising maneuver. The confounding effects of impaired right ventricular function and increased intra-abdominal pressure can be identified. Using a binary cutoff for the fractional change in stroke volume, common in previous clinical research, fails to identify the importance of variables relevant to venous return physiology and confounding conditions.
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Åneman et al. (2023) conducted an observational in Volume responsiveness. Echocardiography combined with venous return physiology (continuous outcomes) vs. Binary cutoff for fractional change in stroke volume was evaluated on Continuous changes in stroke volume following a passive leg raising maneuver. Analog mean systemic filling pressure and venous return pressure gradient combined with echocardiography predict continuous changes in stroke volume following a passive leg raising maneuver.
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