What does this research mean for the field?

Combined tricuspid valve avulsion and pulmonary artery stenosis successfully produces a reliable experimental model of progressive, chronic right-sided cardiac failure in dogs. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to establish a method for inducing chronic cardiac failure in dogs for further research.

January 1, 1950Experimental Biology and Medicine

A Method for Producing Chronic Cardiac Failure in Dogs.

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Population

Dogs (n=3)

Design

Preclinical

Authors

ABA. C. BargerBrigham and Women's Hospital GRG. S. RichardsonUniversity of Ulster BRBenson B. RoeSan Francisco General Hospital

Discussion

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Implication

May aid preclinical right heart failure research; leaves open human translation pending validation.

Key Points

The aim is to establish a method for inducing chronic cardiac failure in dogs for further research.
Induced chronic cardiac failure using tricuspid valve avulsion and pulmonary artery stenosis in three dogs.
Monitored symptoms including elevated auricular pressure, distended veins, and decreased work tolerance.
Examined hearts via heart-lung preparation to assess cardiac insufficiency.
All three treated dogs developed congestive heart failure with significant clinical symptoms.
Symptoms included elevated auricular pressure, decreased work tolerance, and hepatomegaly.
Studies indicated clear evidence of cardiac insufficiency in two hearts examined.

Structured PICO

Population

Dogs (n=3)

Intervention

Tricuspid valve avulsion and pulmonary artery stenosis

Outcome

Development of progressive, chronic, right-sided cardiac failure (indicated by elevated auricular pressure, distended veins, decreased work tolerance, hepatomegaly, ascites, tachycardia at rest, and fixed heart rate during exercise)surrogate

Tricuspid valve avulsion combined with pulmonary artery stenosis provides a viable experimental canine model for producing chronic right-sided heart failure.

Cite This Study

Barger et al. (1950) studied this question.

synapsesocial.com/papers/6a154bde37103a43379f8516 https://doi.org/10.3181/00379727-73-17595

Topics

Heart failure HFrEF treatment

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A Method for Producing Chronic Cardiac Failure in Dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A Method for Producing Chronic Cardiac Failure in Dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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