Elevated METS-IR levels in non-overweight adults were associated with a 96% increased risk of incident hypertension in the highest versus lowest quartile (HR 1.96; 95% CI 1.40-2.76).
Cohort (n=4,678)
No
Does an elevated metabolic score for insulin resistance (METS-IR) predict incident hypertension in non-overweight adults?
Elevated METS-IR is a significant, dose-dependent predictor of incident hypertension in non-overweight Chinese adults, suggesting its potential utility for early risk stratification.
Effect estimate: HR 1.96 (95% CI 1.40-2.76)
BACKGROUND: Insulin resistance (IR) plays an important role in the progression of hypertension (HTN); therefore, early identification of IR is clinically important for preventing HTN. Our study aims to explore the relationship between the metabolic score for IR (METS-IR) and HTN in Chinese population who maintained non-overweight. METHODS: A total of 4678 adults who underwent annual health check-up in our institution from 2010 to 2017, did not have HTN at the first check-up and maintained non-overweight at follow-up were selected as subjects. The baseline METS-IR was calculated and the outcome was incident HTN. Cox proportional hazards regression models were used to evaluate hazards ratios of HTN for METS-IR. Additionally, sensitive analyses and stratification analyses were used to deeply verify the relationship of METS-IR with HTN. The dose-response association between METS-IR and HTN risk was investigated using restricted the cubic spline analysis fitted for the Cox proportional hazards model. RESULTS: Compared with the first quartiles of METS-IR, the risk of incident HTN was increased by 58% hazard ratio (HR) 1.58, 95% confidence interval (CI) 1.12-2.22 and 96% (HR 1.96, 95% CI 1.40-2.76) in the Q3 group and the Q4 group, respectively. The results remained consistent when analyses were restricted to people without abnormal high-density lipoprotein cholesterol, triglyceride or fasting plasma glucose level at baseline. A linear dose-response relationship between METS-IR and HTN risk was identified (HR 1.08, 95% CI 1.04-1.12). CONCLUSIONS: The risk of incident HTN was associated with elevated METS-IR levels in non-overweight individuals. METS-IR could help predict the risk of HTN in non-overweight individuals.
Xu et al. (Wed,) conducted a cohort in Hypertension (n=4,678). METS-IR (metabolic score for insulin resistance) vs. Lowest quartile of METS-IR was evaluated on Incident hypertension (HR 1.96, 95% CI 1.40-2.76). Elevated METS-IR levels in non-overweight adults were associated with a 96% increased risk of incident hypertension in the highest versus lowest quartile (HR 1.96; 95% CI 1.40-2.76).