Effect of Blood Pressure on Early Decline in Kidney Function Among Hypertensive Men
Key result
Blood pressure ≥160/95 mm Hg was associated with a 5.21-fold greater risk of early kidney function decline compared to <140/90 mm Hg in hypertensive men (95% CI 2.06-13.21; P<0.001).
Why the study?
Does higher treated blood pressure increase the risk of early kidney function decline in treated hypertensive men without chronic kidney disease?
Population
722 treated hypertensive men (504 African-American, 218 white) without chronic kidney disease
Comparison
Higher treated blood pressure levels vs Lower treated blood pressure levels
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
Should not yet change BP targets in treated hypertensive men without CKD; leaves open whether intensification prevents early kidney decline.
Study Design
Type
Cohort (n=722)
Structured PICO
Does higher treated blood pressure increase the risk of early kidney function decline in treated hypertensive men without chronic kidney disease?
P
Population
722 treated hypertensive men (504 African-American, 218 white) without chronic kidney disease
I
Intervention
Higher treated blood pressure levels (e.g., ≥160/95 mm Hg or per standard deviation increase)
C
Comparator
Lower treated blood pressure levels (e.g., <140/90 mm Hg)
O
Outcome
Estimated glomerular filtration rate and early kidney function decline (rise in serum creatinine ≥0.6 mg/dL during follow-up)surrogate
Main Result
Effect estimate: RR 5.21 (95% CI 2.06 to 13.21)
p-value: p=<0.001
Higher levels of treated blood pressure are significantly associated with an early decline in kidney function among hypertensive men without chronic kidney disease.
Cite This Study
Vupputuri et al. (2003) conducted a cohort in Hypertension without chronic kidney disease (n=722). Blood pressure ≥160/95 mm Hg vs. Blood pressure <140/90 mm Hg was evaluated on Early kidney function decline (rise in serum creatinine ≥0.6 mg/dL) (RR 5.21, 95% CI 2.06 to 13.21, p=<0.001). Blood pressure ≥160/95 mm Hg was associated with a 5.21-fold greater risk of early kidney function decline compared to <140/90 mm Hg in hypertensive men (95% CI 2.06-13.21; P<0.001).