Lean women with androgen excess PCOS exhibit marked endothelial dysfunction associated with free testosterone levels, which is impaired relative to overweight/obese women with AE-PCOS.
Observational
Does short-term ethinyl estradiol supplementation improve endothelial function in lean women with androgen excess polycystic ovary syndrome?
Lean women with AE-PCOS exhibit marked endothelial dysfunction linked to free testosterone that does not improve with short-term ethinyl estradiol, highlighting a direct vascular effect of androgens.
We present evidence for marked endothelial dysfunction in lean women with androgen excess polycystic ovary syndrome (AE-PCOS) that is 1) associated with free testosterone levels, 2) impaired relative to overweight/obese women with AE-PCOS, and 3) unchanged following short-term ethinyl estradiol supplementation. These data indicate an important direct effect of androgens on the vascular system in women with AE-PCOS. Our data also suggest that the relationship between androgens and vascular health differs between phenotypes of AE-PCOS.
Berbrier et al. (Thu,) conducted a observational in Androgen excess polycystic ovary syndrome (AE-PCOS). Ethinyl estradiol supplementation vs. Overweight/obese women with AE-PCOS was evaluated on Endothelial function. Lean women with androgen excess PCOS exhibit marked endothelial dysfunction associated with free testosterone levels, which is impaired relative to overweight/obese women with AE-PCOS.