Serum levels of endothelin-1 were significantly higher in patients with essential hypertension (5.01 pg/mL) compared to healthy normotensive controls (3.2 pg/mL, p=0.0144).
Case-Control
Absolute Event Rate: 5.01% vs 3.2%
p-value: p=0.0144
The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding. Based on these controversial data, we tested serum levels of ET-1 and Big ET-1 (the precursor of ET-1) in patients with essential HTN, comparing the results with those of healthy normotensive controls. The levels of ET-1 and Big ET-1 were measured by ELISA. Our results in patients with essential HTN showed that the mean levels of ET-1 (5.01 ± 2.1 pg/mL) were significantly higher (F = 6.34, p = 0.0144) than the mean levels in the control group (3.2 ± 1.0 pg/mL). The levels of Big ET-1 in patients with essential HTN (0.377 ± 0.1 pmol/L) were similar to those in the control group (0.378 ± 0.07 pmol/L) and did not differ significantly (F = 0.00, p = 0.9531). These data suggest that ET-1, but not Big ET-1, may play an important role in the pathogenesis of primary HTN.
Kostov et al. (Mon,) conducted a case-control in Essential Hypertension. Essential hypertension (exposure) vs. Healthy normotensive controls was evaluated on Serum levels of ET-1 (pg/mL) (p=0.0144). Serum levels of endothelin-1 were significantly higher in patients with essential hypertension (5.01 pg/mL) compared to healthy normotensive controls (3.2 pg/mL, p=0.0144).
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