What does this research mean for the field?

Patients who die suddenly from long QT syndromes consistently exhibit focal neuritis and neural degeneration within the cardiac conduction system and ventricular myocardium. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

June 1, 1978CirculationOpen Access

De subitaneis mortibus. XXX. Observations on the pathophysiology of the long QT syndromes with special reference to the neuropathology of the heart.

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Population

8 patients from different families with syncopal attacks and a long QT interval in the ECG who died suddenly

Design

Case_series

Authors

TJThomas N. JamesTulane University PFP. FroggattQueen's University Belfast WAWendy AtkinsonAbbott Northwestern Hospital

Discussion

Member takes

Implication

Neural pathology may contribute to long QT sudden death; hypothesis-generating challenge to hereditary model needing confirmation.

Structured PICO

Population

8 patients from different families with syncopal attacks and a long QT interval in the ECG who died suddenly (5 with normal hearing, 3 born deaf)

Outcome

Neuropathological findings in the heart at postmortem examinationsurrogate

Postmortem examination of patients with long QT syndrome who died suddenly revealed consistent focal intracardiac neuritis and neural degeneration, suggesting a potential role of neural disease in the pathogenesis.

Cite This Study

James et al. (1978) studied this question.

synapsesocial.com/papers/6a1c5d41ea84844e355fc9c8 https://doi.org/10.1161/01.cir.57.6.1221

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Bookmark

De subitaneis mortibus. XXX. Observations on the pathophysiology of the long QT syndromes with special reference to the neuropathology of the heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

De subitaneis mortibus. XXX. Observations on the pathophysiology of the long QT syndromes with special reference to the neuropathology of the heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider