A claims-based random survival forest algorithm accurately predicted time to unsatisfactory response following initial PAH therapy (C-statistic 0.732), compared to a simplified risk score (0.668).
Observational (n=4,781)
Can a claims-based predictive algorithm accurately identify patients with PAH at risk of unsatisfactory response to initial therapy?
A claims-based predictive algorithm using factors like healthcare resource use and comorbidities showed good accuracy (C-statistic 0.732) in predicting unsatisfactory response to initial PAH therapy.
Effect estimate: C-statistic 0.732
OBJECTIVE: This study aimed to develop and validate a predictive algorithm for unsatisfactory response to initial pulmonary arterial hypertension (PAH) therapy using health insurance claims. METHODS: Adult patients with PAH initiated on a first PAH therapy (index date) were identified from Optum's de-identified Clinformatics Data Mart Database (1/1/2010-12/31/2019). A random survival forest algorithm was developed using patient-month data and predicted the "survival function" (i.e. risk of not having unsatisfactory response) over time. For each patient-month observation, risk factors were assessed in the 12 months prior. Unsatisfactory response was defined as the first instance of (1) new PAH therapy, (2) PAH-related hospitalization or emergency room visit, (3) lung transplant or atrial septostomy, (4) PAH-related death or (5) chronic oxygen therapy initiation. To facilitate use in clinical practice, a simplified risk score was also developed based on a linear combination of the most important risk factors identified in the algorithm. RESULTS: In total, 4781 patients were included (median age = 69.0 years; 58.6% female). Over a median follow-up of 14.0 months, 3169 (66.3%) had an unsatisfactory response. The most important risk factors included in the algorithm were healthcare resource use (i.e. PAH-related outpatient visits, pulmonologist visits, cardiologist visits, all-cause hospitalizations), time since first PAH diagnosis, time since index date, Charlson Comorbidity Index, dyspnea, and age. Predictive accuracy was good for the full algorithm (C-statistic: 0.732) but was slightly lower for the simplified risk score (C-statistic: 0.668). CONCLUSION: The present claims-based algorithm performed well in predicting time to unsatisfactory response following initial PAH therapy.
Gauthier‐Loiselle et al. (Fri,) conducted a observational in Pulmonary arterial hypertension (n=4,781). Predictive algorithm (random survival forest) vs. Simplified risk score was evaluated on Unsatisfactory response (new PAH therapy, PAH-related hospitalization/ER visit, lung transplant/atrial septostomy, PAH-related death, or chronic oxygen therapy) (C-statistic 0.732). A claims-based random survival forest algorithm accurately predicted time to unsatisfactory response following initial PAH therapy (C-statistic 0.732), compared to a simplified risk score (0.668).