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June 1, 2026Case Reports in Critical CareOpen Access

Complex Metabolic Acidosis: From Case Report to Systematic Approach

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Authors

MRM. ReyskensUniversitair Ziekenhuis BrusselBSBastiaan SolAlmaMRMatthias RaesEuropean Society of Intensive Care Medicine

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Overview

Case report describes mixed acid-base disorders and proposes a systematic diagnosis approach in adults, suggesting awareness of underlying causes.

Key Points

  • To highlight mixed acid-base disorders and present a systematic approach for their diagnosis.
  • Reported on a 61-year-old woman with severe metabolic acidosis and kidney injury, highlighting diagnostic challenges.
  • Initiated continuous venovenous hemofiltration to manage elevated lactate levels and investigate persistent acidosis.
  • Identified multiple factors contributing to metabolic acidosis after normalization of serum lactate levels.
  • Proposed a systematic approach to better diagnose and manage mixed acid-base disorders.

Cite This Study

Reyskens et al. (2026) studied this question.

synapsesocial.com/papers/6a1d22bb02fbce913063867fhttps://doi.org/10.1155/crcc/6121567
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Unusual Case of Metabolic Acidosis: The GAP and Urine are the Clues2024
  2. 2Concurrent Metformin-Associated Lactic Acidosis and Euglycemic Diabetic Ketoacidosis Without Sodium-Glucose Cotransporter 2 Inhibitor Exposure: A Case Report and Literature Review2026 · 1 citations
  3. 3Sociodemographic and Etiological Profile of Patients with Metabolic Acidosis Admitted in an Intensive Care Unit of a Specialized Hospital in Bangladesh2024
  4. 4Normoglycemic High Anion Gap Metabolic Acidosis With Hyperkalemia: An Unusual Presentation of Alcoholic Ketoacidosis2026
  5. 5Metabolic Acidosis in Patients with Chronic Kidney Disease: Diagnosis, Pathogenesis, and Treatment—A Narrative Review2025 · 7 citations