Key result
Long-term intensive endurance exercise training in master athletes did not induce myocardial fibrosis or ventricular dysfunction, demonstrating normal cardiac extracellular volume (21.5%) and no late gadolinium enhancement compared to sedentary controls.
Why the study?
It is debated whether long-term intensive endurance exercise induces chronic cardiac damage such as myocardial fibrosis and ventricular contractile dysfunction.
Does long-term intensive endurance exercise training induce myocardial damage or fibrosis in master athletes?
Cross-Sectional (n=51)
Blinded outcome assessment
No
Does long-term intensive endurance exercise training induce myocardial damage or fibrosis in master athletes?
Absolute Event Rate: 21.5% vs 22%
p-value: p=0.408
Long-term intensive endurance exercise in master athletes induces physiological cardiac remodeling without evidence of myocardial fibrosis or ventricular dysfunction.
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Supports cardiac safety of endurance training in masters without fibrosis; leaves open prospective validation of long-term effects.
Missenard et al. (2021) conducted a cross-sectional in Healthy master athletes (n=51). Long-term intensive endurance exercise training vs. Sedentary controls was evaluated on Cardiac extracellular volume (ECV) (p=0.408). Long-term intensive endurance exercise training in master athletes did not induce myocardial fibrosis or ventricular dysfunction, demonstrating normal cardiac extracellular volume (21.5%) and no late gadolinium enhancement compared to sedentary controls.
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