Putatively deleterious variants in cardiac genes were significantly enriched in patients with acute myocarditis compared to matched controls (16.2% vs 7.2%, OR 2.50).
Case-Control (n=585)
Yes
Do myopathic cardiac genotypes increase the risk for acute myocarditis?
Putatively damaging variants in genes associated with cardiomyopathy and neuromuscular disorders are significantly enriched in patients with acute myocarditis, suggesting a genetic susceptibility to the disease.
Odds Ratio: 2.5 (95% CI 1.35–4.54)
Absolute Event Rate: 16.2% vs 7.2%
p-value: p=0.003
Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac genes were found in 19 of 117 acute myocarditis cases vs 34 of 468 control subjects (P = 0.003). Thirteen genes classically associated with cardiomyopathy or neuromuscular disorders with cardiac involvement were implicated, including >1 associated damaging variant in DYSF, DSP, and TTN. Phenotypes of subjects who have acute myocarditis with or without deleterious variants were similar, indicating that genetic testing is necessary to differentiate them.
Kontorovich et al. (Thu,) conducted a case-control in Acute myocarditis (n=585). Putatively deleterious variants in cardiac genes vs. Matched heart-healthy controls was evaluated on Presence of putatively deleterious variants in genes related to cardiomyocyte structure and function (OR 2.50, 95% CI 1.35-4.54, p=0.003). Putatively deleterious variants in cardiac genes were significantly enriched in patients with acute myocarditis compared to matched controls (16.2% vs 7.2%, OR 2.50).