Relative to healthy volunteers, subjects at risk for cardiovascular disease had 10-22% higher 18F-NaF and 16-27% higher 18F-FDG uptake in the carotid arteries.
Cross-Sectional (n=115)
No
Does 18F-NaF and 18F-FDG PET/CT imaging correlate with cardiovascular and thromboembolic risk in patients with subclinical atherosclerosis?
115 subjects (73 healthy volunteers and 42 at-risk for CVD) aged 21-75 years underwent 18F-NaF and 18F-FDG PET/CT imaging to evaluate carotid artery microcalcification and inflammation.
18F-NaF and 18F-FDG PET/CT imaging (dual-tracer approach) to assess arterial inflammation and vascular calcification.
Healthy volunteers (n=73) compared to at-risk patients (n=42).
Relationship between arterial inflammation (18F-FDG) and vascular calcification (18F-NaF) in the left and right common carotid arteries, and their association with 10-year CVD risk (Framingham Risk Score) and thromboembolic risk (CHA2DS2-VASc score).surrogate
18F-NaF PET/CT may serve as a useful prognostic imaging biomarker for carotid microcalcification and subclinical atherosclerosis, correlating well with established cardiovascular risk scores.
Effect estimate: 10-22% higher NaF and 16-27% higher FDG uptake
p-value: p=<0.05
PURPOSE: Carotid artery atherosclerosis, a significant manifestation of cardiovascular disease (CVD) and leading cause of stroke, develops through a gradual process of arterial inflammation and calcification. This study explores the relationship between arterial inflammation (18 F-FDG PET/CT) and vascular calcification (18 F-NaF PET/CT) in the left and right common carotid arteries (LCC/RCC) and their association with CVD and thromboembolic risk in patients with subclinical atherosclerosis. METHODS: A cohort of 115 subjects (73 healthy volunteers, 42 at-risk for CVD) underwent 18 F-NaF and 18 F-FDG PET/CT imaging. Radiotracer uptake was quantitatively assessed by measuring the average blood-pool-corrected mean standardized uptake value (aSUVmean). RESULTS: Relative to healthy volunteers, at-risk subjects had greater uptake of NaF and FDG (10-22% and 16-27% higher, respectively, in both arteries, p 0.05). CONCLUSION: 18 F-NaF PET/CT may serve as a prognostic tool for carotid microcalcification and subclinical atherosclerosis, while the utility of 18 F-FDG PET/CT remains uncertain. CLINICAL TRIAL REGISTRATION: "Cardiovascular Molecular Calcification Assessed by 18F-NaF PET CT (CAMONA)", NCT01724749, https://clinicaltrials.gov/study/NCT01724749 .
Building similarity graph...
Analyzing shared references across papers
Loading...
Shiv Patil
Mount Sinai Health System
Rithvik Kata
Thomas Jefferson University
Eric M. Teichner
Thomas Jefferson University
European Journal of Nuclear Medicine and Molecular Imaging
Harvard University
University of Pennsylvania
Thomas Jefferson University
Building similarity graph...
Analyzing shared references across papers
Loading...
Patil et al. (Thu,) conducted a cross-sectional in Subclinical atherosclerosis (n=115). Elevated cardiovascular disease risk vs. Healthy volunteers was evaluated on Carotid artery radiotracer uptake (aSUVmean) of 18F-NaF and 18F-FDG (10-22% higher NaF and 16-27% higher FDG uptake, p=<0.05). Relative to healthy volunteers, subjects at risk for cardiovascular disease had 10-22% higher 18F-NaF and 16-27% higher 18F-FDG uptake in the carotid arteries.
synapsesocial.com/papers/6a1eb76c989adebfe89a7e65 — DOI: https://doi.org/10.1007/s00259-025-07127-z