The influence of sex and valve phenotype on fibrocalcific composition in severe aortic stenosis evolves with age

Key Points

• This research aims to assess how sex and valve phenotype affect fibrocalcific composition in patients with severe aortic stenosis as they age.
• Analyzed fibrocalcific composition in patients with severe aortic stenosis based on sex and valve type
• Included a diverse age range to assess changes over time
• Utilized advanced imaging techniques to quantify composition
• Men showed a higher fibrocalcific density compared to women, with significant age-related increases (p<0.05)
• Patients with different valve phenotypes exhibited distinct composition profiles, affecting treatment outcomes
• Age was found to be a critical modifier of fibrocalcific changes, highlighting the need for age-targeted interventions.