Repeated alcohol intake in Japanese males with hypertension initially decreased average systolic blood pressure (from 147.2 to 140.2 mmHg) and urinary sodium excretion, followed by a return to baseline levels.
Does repeated alcohol intake affect blood pressure and sodium balance in Japanese males with hypertension?
Repeated alcohol intake in hypertensive Japanese men causes a biphasic blood pressure response, with an initial decrease accompanied by sodium retention, followed by a return to baseline.
Absolute Event Rate: 140.2% vs 147.2%
p-value: p=<0.05
Alcohol consumption causes biphasic changes in blood pressure (BP) in Asians. The aim of the present study was to investigate the effects of repeated alcohol intake on BP and sodium metabolism. Fourteen Japanese males with hypertension (37-67 years old) were examined under standardized conditions (Na intake 120 mmol/day). After 1 week of alcohol restriction, the patients consumed a control drink with dinner for 3 days, 1 ml/kg of alcohol for the next 7 days, then the control drink for 3 days. Supine BP and heart rate were measured 5 times daily, and urinary excretion of water and sodium was determined throughout the study period. Average BP decreased initially, then returned to the baseline level during the alcohol period. Evening BP decreased significantly throughout the alcohol period, although the reduction was attenuated during the late phase. Morning and afternoon BP did not change significantly, but tended to be elevated during the late phase. Heart rate increased both in the morning and evening during the alcohol period. Urine volume did not change during the early phase, but increased significantly during the late phase. Urinary sodium excretion decreased initially, but increased during the middle phase of the alcohol period. In conclusion, BP decreases initially with sodium retention, then returns to the baseline level with restoration of sodium balance during repeated alcohol intake in Japanese males with hypertension. Sodium retention during the early phase appears to be the consequence of BP reduction and may contribute to the subsequent changes in BP.
Kawano et al. (Thu,) conducted a other in Essential hypertension (n=14). Repeated alcohol intake vs. Nonalcoholic control drink was evaluated on Average systolic blood pressure on Day 1 of alcohol intake (p=<0.05). Repeated alcohol intake in Japanese males with hypertension initially decreased average systolic blood pressure (from 147.2 to 140.2 mmHg) and urinary sodium excretion, followed by a return to baseline levels.